Should not be used to treat depression failed to respond to other SSRIs, but may be considered for people with severe depression who responded to other SSRIs but have been unable to tolerate side effects.
Worst side effects profile: weight gain, sexual dysfunction, sedation, and anticholinergic side effects! Significantly more problems on discontinuation than with other SSRIs.
It is impossible to recommend antidepressant effective for all patients.
Sertraline (Zoloft) and escitalopram (Lexapro) are considered to have the best combination of efficacy and acceptability .
Tricyclic Antidepressants (TCAs) were developed in the 1950s as a way to treat depression with chemical compounds.
These drugs are known for their specific chemical structure consisting of three rings of atoms, hence being referred to as “tri”-cyclic.
In addition to resolving sleep-related symptoms through their primary therapeutic effects, many psychiatric medications have secondary effects on sleep that can contribute to their overall therapeutic benefit or sometimes counter them through adverse effects.